Gate1Travel.com offers some unbelievable bargains for flight and hotel packages (they also offer all-inclusive tours if you’re interested in that sort of thing)…sign up on their email list to
see featured deals.

Skoosh.com - UK run site, offered best price for our hotel in L.A. The
downtown Omni hotel usually charges $250 per night (for starters).
The other hotel sites were advertising nightly rates in the ballpark
of $189. We booked our room through Skoosh for only $139!

Kayak.com - I researched flights to Italy extensively before purchasing
since the cost for such has sky-rocketed over the last few years. The
site that finally won my bid for offering the lowest price was
Kayak.com.

Skybus.com - If you happen to live in North Carolina or Ohio, or need to travel to either, then Skybus just may have your ticket. They sell their flights in one-way segments which happen to all be non-stop. The
first ten seats of each and every flight sell for only $10!! Even if
you aren’t quick enough to snatch up one of those (I was fortunate to
get a flight to L.A. for $20 from Greensboro), the flights are
amazingly reasonable. I check their sight on occasion and they
frequently have availability on $40 fares. That still comes out to be
a non-stop flight for $80! Check them out at Skybus.com and
sign up for their email alerts as they continue to add new cities!

**One thing to note: Some of the sites that offer discounted rates on
hotels actually charge a fee per night on top of any other
service fees & taxes. Make sure your final price is still a good
deal, or you are better off booking through the hotel directly. There
is no sense in adding a middle-man to your reservation if you’re not
saving a fair amount of money.